Mesenchymal Stem Cell (MSC)-derived exosomes represent a cutting-edge, cell-free approach in aesthetics, utilizing the powerful natural messengers from stem cells to induce repair and regeneration without injecting any living cells.
These nanovesicles carry a rich cargo of bioactive molecules, including growth factors, anti-inflammatory proteins, and genetic material (miRNA), which signal your body's existing cells to rejuvenate.
MSC exosome therapy is highly versatile and is used to address the cellular root causes of aging, inflammation, and tissue damage.
Skin Rejuvenation | Anti-Aging
Exosomes signal skin cells to increase the production of essential youth-sustaining proteins, resulting in significant aesthetic improvement:
Collagen & Elastin Boost: Exosomes actively stimulate fibroblasts to produce new collagen and elastin, leading to firmer, more resilient skin and a reduction in fine lines and wrinkles.
Texture and Tone: They accelerate cell turnover and repair, reducing the appearance of enlarged pores, rough texture, and sun-induced discoloration.
Reduced Inflammation: Their potent anti-inflammatory properties quickly calm reactive skin, making them ideal for use post-procedure (e.g., laser or microneedling) or for treating conditions like rosacea and chronic redness.
Scars and Wounds
MSC Exosomes optimize healing by switching the body from scar-forming mode to regenerative repair.
Anti-Scarring Signal: They rapidly deliver anti-inflammatory proteins to the site of injury, which is critical for preventing the prolonged inflammation that leads to thick, rigid scarring (hypertrophic and keloid).
Quality Collagen Production: Exosomes guide fibroblasts to produce Type III collagen (found in healthy, elastic skin) rather than the rigid Type I collagen that dominates scar tissue. This action ensures wounds heal smoother, faster, and with better aesthetic quality.
Accelerated Closure: Growth factors within the exosomes drive the quick migration of skin cells (keratinocytes and fibroblasts), significantly speeding up wound closure and reducing recovery time after aesthetic procedures (like deep lasers or micro needling).
Hair Restoration
Delivered via targeted injection into the scalp, MSC Exosomes deliver the precise signals needed to combat hair thinning and loss.
Follicle Activation: The exosome cargo is packed with essential growth factors (like VEGF and IGF-1). These messengers signal miniaturized and dormant hair follicles to transition from the resting (Telogen) phase back into the active growth (Anagen) phase.
Anti-Miniaturization: They nourish and strengthen the dermal papilla, the core structure responsible for hair production. This helps reverse the shrinking of hair follicles, leading to thicker, healthier hair shafts over time.
Optimal Scalp Environment: Exosomes reduce the inflammation and fibrosis around the hair bulb, creating a supportive, anti-inflammatory environment that is essential for sustained, robust hair growth and improved density.
We've created two fantastic methodologies for receiving exosome treatments, offering flexibility and targeted results. We deliver the powerful regenerative potential of exosomes through both topical application for focused skin and hair restoration, and a precise injection method designed for deeper, longer-lasting cellular revitalization.
Direct & Potent Cellular Treatment
For the most direct and potent cellular treatment, the precise injection method delivers a highly concentrated dose of exosomes straight to the target area—whether that's the deeper layers of the skin, the scalp for hair restoration, or localized areas of concern. This ensures the exosomes' powerful cargo of growth factors and signaling molecules immediately begins the work of cellular communication, deep tissue repair, and targeted regeneration, promoting more profound and lasting results.
Non-Invasive, Easy Application
For those seeking non-invasive and easy application, our topical method allows for the powerful benefits of exosomes to be gently absorbed. By delivering the concentrated regenerative factors directly onto the skin or scalp's surface, this method supports surface-level rejuvenation, enhances skin texture, reduces inflammation, and encourages a healthier healing environment without the need for needles. It’s the perfect way to incorporate cutting-edge cell-free therapy into your daily routine.
Exosomes represent a significant leap forward in regenerative aesthetics, offering the potent signaling power of stem cells without the use of any living cells. This allows for a superior, safer, and often more efficient alternative to older technologies like cellular therapies or traditional blood products.
Exosomes carry no cellular DNA, eliminating the risk of immune rejection or unwanted cell growth (unlike whole stem cells).
They carry a highly concentrated, synergistic payload of regenerative factors far surpassing traditional treatments like Platelet-Rich Plasma (PRP).
Because they accelerate the body's natural healing pathways, treatments typically involve less redness and recovery time than standalone procedures.
Syringe-Based (Injected): This method targets specific, deeper tissues (like joints, tendons, or the scalp) or uses intravenous (IV) delivery for systemic, whole-body benefits. It allows for a higher concentration of exosomes to be delivered directly to the site of damage, promoting regeneration and reducing deep inflammation.
Topical (Surface Applied): This method is typically used for aesthetic purposes (skin rejuvenation, anti-aging, scarring). The exosomes are applied to the skin's surface, often following a procedure like micro needling or laser treatment, to enhance skin repair, boost collagen production, and reduce surface inflammation.
Injected Exosomes: Primarily used for musculoskeletal issues (e.g., osteoarthritis, tendonitis, ligament tears), chronic systemic inflammation, certain neurological support, and deeper applications like hair restoration (injected into the scalp).
Topical Exosomes: Primarily used for surface issues like fine lines, wrinkles, acne scars, hyperpigmentation, and general skin texture and tone improvement. They leverage the exosomes' cargo to stimulate localized cellular turnover and repair.
Initial Results: With topical applications, patients often notice a "glow" and improved hydration within days, with true regenerative results appearing in 4–6 weeks. For injected treatments, functional improvement (like reduced joint pain) typically begins in 4–8 weeks, peaking at 3 to 6 months.
Longevity: Because exosomes initiate a natural regenerative process, the effects are long-lasting, often sustained for 6 to 18 months or more, depending on the treated condition, the individual's overall health, and lifestyle factors. Maintenance treatments may be recommended.
Safety: MSC-derived exosomes are generally considered a low-risk, cell-free therapy. Unlike whole stem cells, they cannot replicate or differentiate, eliminating the risk of tumor formation or immune rejection.
Side Effects:
Injected: Minor, temporary side effects may include localized pain, swelling, redness, or bruising at the injection site, similar to any injection.
Topical: Minor side effects are usually limited to mild, temporary redness or tingling, particularly when combined with micro needling.
Currently, no exosome product is fully approved by the U.S. Food and Drug Administration (FDA) for the general treatment of specific diseases or for broad cosmetic use.
The FDA classifies exosomes derived from human tissue as biological drug products and is actively regulating them. Many clinics offer these treatments under the legal practice of medicine and science based on ongoing research and clinical experience, but patients should be aware that they are not yet fully FDA-approved commercial products.
While a single injected treatment can offer noticeable relief, a series of treatments (typically 2–4 sessions) spaced several weeks apart is often recommended to maximize and sustain the regenerative effects, particularly for chronic conditions or significant aesthetic goals (like severe hair loss or scarring). The exact protocol depends entirely on the specific application and the patient's individual response.
At B&H BIO, We've created two fantastic methodologies for receiving exosome treatments, offering flexibility and targeted results. We deliver the powerful regenerative potential of exosomes through both topical application for focused skin and hair restoration, and a precise injection method designed for deeper, longer-lasting cellular revitalization.
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Regulatory Notice Regarding Exosome Products
It's crucial to understand the current regulatory status of these products:
These exosome products are intended solely for investigative research purposes and are not approved by the FDA (U.S. Food and Drug Administration) for use as treatments or therapies.
Patients and healthcare providers must exercise extreme caution. Before considering the use of stem cell-derived exosomes for any medical condition, you should thoroughly consult with regulatory authorities and experts. Do not use these products outside of a properly authorized clinical trial.